Crohn's disease treatment with stem cell therapy – BioAge
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Crohn's disease treatment with stem cell therapy

Improvement of bowel function after treatment with human umbilical cord mesenchymal stem cells for Crohn’s disease:
Introduction
Crohn’s disease is an inflammatory bowel disease that usually affects the end of the ileum – the intestine, but can affect the entire gastrointestinal tract , from mouth to anus. Left untreated, Crohn’s disease can cause inflammation throughout the gastrointestinal tract, causing pain, discomfort, irregular bowel movements, and digestive problems. The anti-inflammatory properties of mesenchymal stem cells may relieve negative symptoms associated with Crohn’s disease.

Case Description
We are reporting the case of a 25-year-old female patient previously diagnosed with Crohn’s disease. She was diagnosed with Crohn’s disease in 2011 and also had adrenal and thyroid problems, as well as anemia associated with gastrointestinal bleeding. She was assigned a protocol for the implantation of human umbilical cord mesenchymal stem cells. This protocol consists of intravenous implantation of up to 300 million human umbilical cord mesenchymal stem cells at a rate of 1 cubic centimeter per minute. Three months after treatment, the patient reported a significant improvement in symptoms. During a follow-up medical examination, she reported complete disappearance of symptoms of pain in the intestines and abdomen and a significant improvement in energy, allowing her to return to work for the first time in many years.
Conclusions
The introduction of human umbilical cord mesenchymal stem cells led to a significant improvement in defecation, elimination of abdominal discomfort and elimination of blood entering the rectum. The patient was able to stop taking steroid medications after treatment and noted a sustained improvement in her quality of life.
Background
There is currently no known cure for Crohn’s disease. Fortunately, this condition can be managed with the right treatment regimen. Common medications used to treat Crohn’s disease include anti-inflammatory drugs (steroids, etc.), pain relievers, immunosuppressants (to control the body’s inflammatory response), antibiotics, and surgery (to remove the affected part of the intestinal tract).
Unfortunately, all of these medications are only aimed at reducing the severity of symptoms and may have little effect on the underlying cause of the disease, inflammation. In addition, anti-inflammatory drugs can cause many side effects, many of which can cause even more discomfort or even cause serious complications.

Stem cell therapy can help Crohn’s patients by reducing inflammation. through the digestive tract, regulating the immune system (to control the immune response) and repairing damaged tissue in the gastrointestinal tract.

Stem cell research has shown that cell therapy can help repair diseased, dysfunctional, or damaged tissue.

The therapeutic use of stem cells as a potential treatment for various diseases has been extensively studied. The number of clinical trials conducted with mesenchymal stem cells has increased exponentially over the past few years.

Stem cells have a unique intrinsic property that attracts them to inflammation in the body. Research has shown that stem cells can regenerate damaged or diseased tissue, reduce inflammation, and modulate the immune system, contributing to improved health and quality of life. Mesenchymal stem cells (MSCs) do this by influencing tissue repair through paracrine effects (signaling cellular signals to change the behavior of existing cells) or through direct cell-to-cell contact.
Case presentation
We are only talking about one patient, and on her example we show how it works. The woman was diagnosed with Crohn’s disease and had a history of postural orthostatic tachycardia syndrome, as well as problems with the adrenal glands, thyroid gland and anemia. Basically, she lived without these indications until 2011, when her condition worsened, which required medical intervention. She reported low energy levels, frequent bowel movements, bloody diarrhea, abdominal pain and cramps.She was prescribed Decedrone 0.75 mg and an infusion of Remicade (a TNF-alpha blocker) for inflammation, as well as medicines for diarrhea, nausea and reflux. She also took the drug Norco for pain relief. The patient reported that she could not function normally from day to day, dropped out of school.

Preliminary laboratory work was carried out to establish baseline. The labs required include inflammatory markers to document any abnormally high levels of inflammation that one would expect in Crohn’s disease patients. Her blood count showed TNF Alpha 8.3 (normal range 0.0-2.2). The patient also completed a viability questionnaire that assessed her subjective health in 24 different general health indicators for comparison after treatment.

The patient did not have significant changes in blood pressure, blood oxygen levels, or body temperature during treatment. She did not report any adverse reactions until 24 hours after the date of treatment.

Three months after treatment, the patient reported a significant improvement in symptoms. During the follow-up medical examination, she reported complete disappearance of the symptoms of pain in the intestines and abdomen. The questionnaire of her viability after treatment showed a 95% improvement in bowel movements, elimination of discomfort in the abdomen and blood in the rectum, and an increase in energy levels by 70%. Her bowel movements decreased from 12 per day to 1 per day, and her blood in the rectum from 8 to 10 per day to zero. She reported that she had not taken Daedron since treatment without any side effects. She retained a higher energy level and reported that she started attending school again to pursue higher education, which was not possible before treatment.

Six months after the treatment, the patient underwent a course of diagnostics: colonoscopy and endoscopy with medical specialists. There were no signs of abnormal bowel inflammation, scarring, or fistula. She also stopped taking steroids completely. The patient noted sustained higher energy levels, regular bowel movements and less fatigue, resulting in an improved quality of life.

Discussion
Crohn’s disease affects approximately hundreds of million adults a year. Although the official cause remains unknown, symptoms may be related to inflammation of the gastrointestinal tract from the mouth to the anus. Symptoms include abdominal pain, diarrhea, fever, and weight loss. It is now believed that a combination of environmental, immune, and bacterial factors in genetically susceptible individuals can cause Crohn’s disease.

Mesenchymal stem cells are primary or “undifferentiated” cells. In fact, they are “empty” and can become almost any other type of cell. In the body, their function is to look for damaged or diseased tissues and repair or replace them. We all have a supply of stem cells when we are born, but this decreases over time, and their effectiveness decreases with age. Stem cell transplantation aims to increase the number of stem cells in the body by hundreds of millions. Thanks to the use of donor stem cells obtained from the umbilical cord tissue, the cells used in the treatment are “completely new”, with the highest efficiency and therapeutic potential. In addition, only natural cellular products are used in the treatment, avoiding the use of potentially harmful additives and drugs.
Stem cells have been proven to have strong anti-inflammatory properties. Due to the use of transplants of a large number of cells, young stem cells have a regulatory nature in the body. They can reduce the immune effect that the body cannot regulate on its own. In particular, MSCs can suppress the overproduction and use of T cells in the body. This effect occurs without compromising the body’s natural immune system and does not make the patient vulnerable to disease. The effect of the graft is the return of the body to normal immune function and a sharp decrease in the markers of inflammation in the patient. This anti-inflammatory effect can last for years without the need for a second transplant. For patients with autoimmune and degenerative diseases, this means a natural solution to their symptoms, relief from discomfort and an overall improvement in the quality of life. In addition, not only will the body be better able to repair damaged tissue with less inflammation, but stem cells will also promote faster healing within the body. It is for this reason that even healthy patients turn to stem cell therapy as a form of “body support” and keeping natural inflammation at a manageable level.
Conclusion
Human umbilical cord stem cells have been shown to have important anti-inflammatory and regenerative properties that positively affect the symptoms of Crohn’s disease without any adverse reactions.

 

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