New possibilities of cell therapy to improve fertility

What are the possibilities of cell therapy to restore fertility? Which cells are the most effective and safest?
This question is an area of ​​active research and practice protocols.
Dr. Frances Werther, from CellTrials.org, analyzed 5695 clinical trials using stem cells from various sources and provided data from 112 2011-2020 studies looking at medical diagnoses that affect fertility.
Male problems include:
▪ erectile dysfunction
▪ Peyronie’s disease
▪ low sperm count (azoospermia)
Women’s problems include: 

▪ ovarian failure
▪ violation of the uterine lining (endometrium), including: thin endometrium
– unsuccessful implantations in IVF assisted reproduction cycles
▪ internal adhesions in female reproductive organs and Asherman’s syndrome.
It is known that the endometrium contains its own stem cells, which have a regenerative potential. But to get them, you need to carry out rather complex manipulations, in addition, it is quite expensive.
For clinical trials, most often stem cells are used from a woman’s own bone marrow or from donor material collected during childbirth (from the umbilical cord, umbilical cord blood and placenta).
It is stem cells from postnatal tissues that have proved to be the most promising for treatment, because they are active and have the greatest therapeutic potential, they are obtained ethically, and their use is safe.
Clinical studies in women have shown that implantation of stem cells into the uterus increases the thickness of the endometrium over a long period of time.
The therapy works independently of the engraftment of stem cells directly into the endometrium itself. The basis is paracrine action, that is, the injected stem cells intravenously into the patient’s body, which affects the ability of the woman’s body to recover on its own, and makes the treatment safer and more effective.
In 2011, after cell therapy, a woman with Asherman’s syndrome became pregnant for the first time. In Asherman’s syndrome, the mucous membrane of the uterus is completely replaced by fibrous tissue and adhesions, and independent pregnancy is almost impossible. For such women, the only way to have a genetically natural child is to use the services of a surrogate mother.

It is also quite common to deal with hormonal imbalance in both men and women. This imbalance can be against the background of age-related changes (aging of the body), also as a result of surgical procedures, related diseases, after taking strong corrective or restorative therapy. For such patients, we definitely recommend bioidentical hormone therapy, which:
– balances the level of hormones
– does not suppress the functions of the own sex glands
– is completely safe for the patient and has no side effects phenomena
– identical in molecular formula to human hormones
– after a full examination and finding out the reason, our doctors will select the necessary complex and dosage of bio hormones to return your body to a reproductive state.
In this area there is still a lot to be done, grouped and come to one conclusion, because the studies differed in the type of cells, their number, the method of delivery of cells to the endometrium. But those steps and achievements, which are already known now, are very optimistic.
Cellular therapy to restore fertility is the only parenting opportunity for many families. Potentially, this treatment can become less expensive and more affordable than surrogacy.